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KMID : 1001020120100030113
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Korean Journal of Urological Oncology
2012 Volume.10 No. 3 p.113 ~ p.118
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Translation Researches Using Genome-wide Association Studies(GWAS) in Bladder Cancer
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Yun Seok-Joong
Kim Wun-Jae
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Abstract
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The advent of the genome era after the completion of the Human Genome Project has resulted in intensive efforts to identify all genetic changes that modify human health and disease, including cancer. Genome-wide association studies(GWAS) use high-throughput genotyping technologies to assay hundreds of thousands of single-nucleotide polymorphisms(SNPs) and relate them to clinical conditions. Since 2008, several GWAS have been published for identifying genetic susceptibility loci for bladder cancer. Herein, we review the GWAS data of bladder cancer and summarize the results. Although there is a criticism about the relevance of the GWAS results, it could facilitate the development of a comprehensive risk prediction model which integrates genetic, environment, and person risk factors to benefit disease diagnosis, prevention, and treatment for bladder cancer.
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KEYWORD
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Genome-wide association study, Bladder cancer, Single-nucleotide polymorphism
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